Within this project there are two vacant positions for PhD students.
1. The primary aim of the first project is the development of prognostic models for the response to pharmacological treatment by CHF patients. The prognostic models concern mortality and morbidity of the patients and will be based on well known statistical methods using established risk factors of CHF as well as new biomarkers identified from genome-wide and proteome-wide biomarker identification. The prognostic models will be developed from the primary BiOSTAT-CHF sample and will be validated in a well characterized second sample.
2. The primary aim of the second project is the development of a systems biology approach to link the multidimensional clinical phenotypes of the CHF-patients and their outcome to genetic markers, gene transcription and translation levels in peripheral blood cells. Aim is to derive concise causal pathogenetic pathways that link the genetic and molecular data to the different CHF phenotypes and outcomes. For this project it is necessary to develop new statistical and bioinformatics methods.
- Employment by the AMC Medical Research foundation for a period of 12 months, with possible extension of the contract to 48 months.
- A gross salary will be € 2.107,00 per month in the first year, with an increase to the maximum of € 2.700,00 per month in the fourth year. In addition the AMR BV has an End of Year Bonus of 8.3% and a holiday payment of 8% of the gross yearly salary.
- As a PhD candidate, you are entitled to follow courses provided by the AMC Graduate School.