Showing posts with label Medicine. Show all posts

Thursday, 10 January 2013

VACANCY: Structural and functional imaging Ph.D. candidate

Structural and functional imaging Ph.D. candidate m/f, vacancy number 2012/0603

Location	Utrecht, provincie Utrecht
Function types	Research, Development, Innovation
Scientific fields	Health, Behaviour and Society
Hours	36.0 hours per week
Education	University Graduate
Job number	2012/0603
Translations	en

Apply for this job within 41 days

Job description

ALS is a neurodegenerative disease characterized by both lower as well as upper motor neuron degeneration. Recent advances in MR imaging have made it feasible to examine in ever increasing detail the upper motor neuron effects in ALS, enabling the in vivo examination of neurodegenerative effects on both the structure as well as the connectivity architecture of the brain. This project concerns investigating the integrity of the motor network in ALS using MR imaging. You will acquire multiple forms of morphological and connectivity data in ALS patients and healthy controls, covering high-field structural and functional connectivity data (3T, 7T, T1, Spectroscopy, Diffusion Weighted Imaging, rs-fMRI) and analyze this data with graph analytical tools, examining the effects of structural damage to the brain’s functional dynamics. Your research should result in scientific papers in international journals, and a dissertation.

Requirements

We are looking for motivated candidate, who is enthusiastic about brain (dys)connectivity. You should have a M.Sc. degree in a relevant discipline, such as neuroscience, artificial intelligence, informatics, physics, or medicine. You should also have a wide interest in medical science and an open view to novel methodology. Experience with MRI is a plus. You must have programming experience (e.g. C, matlab, R) and excellent writing skills.

Conditions of employment

For this full-time post, the salary will be according to the scale for Ph.D. internships. This will be a temporary appointment for 4 years.

Contract type: Temporary, 4 years

Department

the department of Neurology of the University Medical Center Utrecht

The research will be carried out under Professor Leonard van den Berg at the department of Neurology of the University Medical Center Utrecht (part of the Rudolf Magnus Institute of Neuroscience). You will be part of an energetic and highly multidisciplinary team, including people with backgrounds in clinical trials, epidemiology, neuroinformatics, mathematics, physics, genetics, and medicine. The team conducts research into motor neuron disorders, including ALS.

More information about employer University Medical Center Utrecht (UMC Utrecht) on AcademicTransfer. Direct link to this job opening: www.academictransfer.com/16887

original here: http://www.academictransfer.com/employer/UMCU/vacancy/16887/lang/en/

Saturday, 7 July 2012

VACANCY: researcher at Amsterdam hospital

Job AMC - AMC Fellowship

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AMC Fellowship

Specifications - (explanation)

Location	AMSTERDAM
Function types	Research, Development, Innovation
Scientific fields	Health
Hours	36.0 hours per week
Education	University Graduate
Job number	60015954-ACT-NL-060710
Translations	en

Apply for this job within 30 days

Job description

We have the following expectations:
Only one prestigious AMC Fellowship is available to attract an outstanding, internationally recognised researcher, who is able to develop his/her own research line and to set up his/her own research group. The candidate must have the potential to advance to full professorship within eight years. The AMC Fellowship spans a five-year period with interim evaluation after three years. The fellowship consists of € 700,000 covering the salary of the fellow, the salary of a PhD student and their bench-fees. The fellowship might include a tenure track with the possibility to acquire a tenured position after 5 years. The AMC Tenure Track is a stimulating 5-year career and personal development trajectory in a challenging research environment.
The AMC provides Tenure Tracks for talented mid-career laureates. Applications are now open. See vacancy "AMC Tenure Track" for more information.

Requirements

• Prestigious personal grant laureate with:
- an (active) VIDI, ERC Starting/ Consolidator grant or an equivalent
or
- a (nearly) successful completion of a prestigious personal grant at junior postdoc level such as VENI or equivalent from foreign funding agencies
• Alignment of their research topic with AMC's thematic profile
• Excellent publication record
• Experience in research management
• Demonstrable affinity with education
• Experience abroad
There will be a strict selection procedure and an assessment might be part of the selection.

Conditions of employment

We offer ample opportunities for further training, for developing greater depth and breadth: a place to grow, in other words! Working at AMC means working in an inspiring and professional environment in which developing one's talents and skills is encouraged.
You are welcome to apply directly by using the button ‘solliciteren/apply' and send in the following documents:
• The AMC Fellowship form including your research plan, CV and planned position in the AMC. The form can be downloaded at www.amc.nl/[...]
• A nomination letter by an AMC department head addressed to the Executive Board of the AMC Research Council, prof. dr. T. van der Poll.
For more information about the AMC Fellowship you can contact dr. S.A.M. van Vliet, AMC Research Office, AMCfellowship@amc.nl, 020-5667806

Contract type: Temporary,

Organisation

AMC

The AMC is more than just a hospital. It is a world in which patient care, research and education are integrated, and in which people are always central. It is an academic world full of possibilities for talented individuals that are looking for a place where they can excel. Thinking big, daring to dream, cooperating internationally. And never letting yourself be put off by ‘It's not possible' or 'It won't work anyway'. That is the AMC mentality.

More information about employer Academic Medical Center (AMC) on AcademicTransfer. Direct link to this job opening: www.academictransfer.com/14799

Wednesday, 2 May 2012

VACANCY: PhD-student, FHML/School for Cardiovascular Diseases

PhD-student, FHML/School for Cardiovascular Diseases (CARIM)/vakgroep Interne Geneeskunde

Specificaties - (uitleg)

Locatie	Maastricht 6200 MD Limburg
Functietypes	PhD positions
Wetenschappelijke discipline	Health
Uren	38.0 uren per week
Salaris	€ 2042 - € 2612
Werk-/denkniveau	University Graduate
Vacaturenummer	AT2012.74
Vertalingen	en

Solliciteer binnen 11 dagen op deze vacature

Functiebeschrijving

The applicant will conduct research in the vascular research group of the dept. of Internal Medicine. This research is embedded in theme Vascular biology of the Cardiovascular Research Institute Maastricht (www.carim.unimaas.nl/).
A growing body of evidence demonstrates that increased adipose mass and the induced expression of adipokines contribute directly towards the burden of insulin resistance and the development of type 2 diabetes. We recently found that the accumulation of the advanced glycation/lipoxidation endproduct (AGEs/ALEs) N-(Carboxymethyl)lysine (CML) in the expanding adipose tissue and activation of the CML-RAGE axis in adipocytes is a novel mechanism contributing to the dysregulation of adipokines. Moreover, activation of the CML-RAGE axis decreased the expression of glyoxalase-1 i.e the enzyme detoxifying the main AGE precursor methylglyoxal (MG), in adipocytes. Our hypothesis is that inhibition of the accumulation of CML and formation of MG leads to amelioration of adipose-tissue derived adipokines and a decreased risk for the development of obesity-associated insulin resistance and type 2 diabetes. The main objectives of this study are to elucidate the association of CML and MG in adipose tissue with progression of insulin resistance and to elucidate whether intervention strategies to inhibit CML and MG accumulation are able to attenuate the development of insulin resistance. We will investigate whether intervention strategies to inhibit CML and MG accumulation are able to attenuate the impaired adipokine-profile in obesity and to improve insulin sensitivity (animal studies) and whether MGO and/or MGO-derived AGEs are directly involved in vascular insulin resistance/signaling (ex-vivo studies). The impact, from a clinical point of view, will be that this study will lead to new possibilities for intervention.

Functie-eisen

Degree in biology, biochemistry, medicine or health sciences. Experience with animal work is a prerequisite and possession of a Laboratory Animal license is an advantage. Subsequent to the PhD project, there will be the possibility for candidates with a degree in medicine of a residency program in Internal Medicine

Arbeidsvoorwaarden

The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website www.maastrichtuniversity.nl/, A-Z Terms of Employment.
Temporary employment for 4 years.
Your salary would be € 2.042,-- gross per month in the first year up to € 2.612,-- gross per month in the fourth year according to the PhD-student salary scale.
Each year an evaluation will take place.

Dienstverband: Temporary, 4 years

Organisatie

http://www.maastrichtuniversity.nl/

Maastricht University is renowned for its unique, innovative, problem-based learning system, which is characterized by a small-scale and student-oriented approach. Research at UM is characterized by a multidisciplinary and thematic approach, and is concentrated in research institutes and schools. Maastricht University has around 14,500 students and 3,800 employees. Reflecting the university's strong international profile, a fair amount of both students and staff are from abroad. The university hosts 6 faculties: Faculty of Health, Medicine and Life Sciences, Faculty of Law, School of Business and Economics, Faculty of Humanities and Sciences, Faculty of Arts and Social Sciences, Faculty of Psychology and Neuroscience.

Additionele informatie

For more information:
Prof Dr. C.G. Schalkwijk, Department of Internal Medicine
email C.Schalkwijk@Maastrichtuniversity.nl
tel: +31 43 3882186

Prof dr CDA Stehouwer, Department of Internal Medicine
email: cda.stehouwer@mumc.nl
tel: +31 43 3877006
For more information about the procedure
Ms M. Berghof
email: martine.berghof@maastrichtuniversity.nl
tel: +31 43 387 2835

Apply here: http://www.academictransfer.com/employer/UM/vacancy/13900/lang/en/

Monday, 9 January 2012

2 PhD Students Tailored Treatment and systems biology of Chronic Heart Failure

Specificaties - (uitleg)

Functietypes	PhD positions
Wetenschappelijke discipline	Health
Uren	36.0 uren per week
Salaris	€ 2107 - € 2700
Werk-/denkniveau	Higher Professional Education +
Vacaturenummer	MR0329
Vertalingen	en

Solliciteer binnen 28 dagen op deze vacature

In Europe the prevalence of heart failure (HF) is about 10-20 in 1000 persons and the prevalence is rising due to the ageing European population. In persons over 75 years of age about 10% is affected. Despite major improvements in the last decennium, prognosis and quality of life of CHF patients is limited. One of the reasons is that response to pharmacological treatment varies between individuals. To investigate markers of treatment-response, 5000 HF patients will be followed in the BiOSTAT-CHF project for mortality, hospitalization and their quality of life. Demographic data, established biomarkers and new genomic and proteomic biomarkers will be combined in prognostic models to predict treatment-response. The BiOSTAT-CHF is an EU-funded project with collaborators from France, Greece, Germany, Italy, the Netherlands, Norway, Poland, and the UK (www.biostat-chf.eu).
Within this project there are two vacant positions for PhD students.
1. The primary aim of the first project is the development of prognostic models for the response to pharmacological treatment by CHF patients. The prognostic models concern mortality and morbidity of the patients and will be based on well known statistical methods using established risk factors of CHF as well as new biomarkers identified from genome-wide and proteome-wide biomarker identification. The prognostic models will be developed from the primary BiOSTAT-CHF sample and will be validated in a well characterized second sample.

2. The primary aim of the second project is the development of a systems biology approach to link the multidimensional clinical phenotypes of the CHF-patients and their outcome to genetic markers, gene transcription and translation levels in peripheral blood cells. Aim is to derive concise causal pathogenetic pathways that link the genetic and molecular data to the different CHF phenotypes and outcomes. For this project it is necessary to develop new statistical and bioinformatics methods.

Functie-eisen

We look for investigators with a master of science in medicine, biomedical/life sciences or (clinical) epidemiology (project 1) and investigators with a master of science in bioinformatics or mathematics/statistics (project 2). For both projects a very good command of the English language (spoken and in writing) is required because of frequent and intensive contacts with partners in the BiOSTAT-CHF project. Experience with clinical research and CHF is preferred but not a prerequisite. Candidates must be willing to travel to participating centers across Europe.

Arbeidsvoorwaarden

- A full time PhD position with the possibility to participate in the exiting BiOSTAT-CHF project and to write PhD-theses on developing future tools for personalized medicine and understanding molecular biological underpinnings of chronic heart failure.
- Employment by the AMC Medical Research foundation for a period of 12 months, with possible extension of the contract to 48 months.
- A gross salary will be € 2.107,00 per month in the first year, with an increase to the maximum of € 2.700,00 per month in the fourth year. In addition the AMR BV has an End of Year Bonus of 8.3% and a holiday payment of 8% of the gross yearly salary.
- As a PhD candidate, you are entitled to follow courses provided by the AMC Graduate School.

Dienstverband: Temporary, 12 months, with possible extension of the contract to 48 months

Tuesday, 20 December 2011

International post-doc position for microRNA therapeutic in heart failure induced by the metabolic risk

Specificaties - (uitleg)

Locatie	Maastricht 6200 MD Limburg
Functietypes	Postdoc positions
Wetenschappelijke discipline	Health
Uren	38.0 uren per week
Salaris	€ 2379 - € 3755
Werk-/denkniveau	Doctorate
Vacaturenummer	AT2011.179
Vertalingen	en

Solliciteer binnen 27 dagen op deze vacature

Functiebeschrijving

Position at the post-doctoral level for 2 years at the University of Maastricht, Cardiovascular Research Institute Maastricht, Cardiology Department.

Within European FP7 Marie Curie Work Programme coördinated by Prof.dr. S. Heymans, we are looking for an excellent, highly competitive researcher at the post-doc level.

Topic
Development of microRNA-medicines for Cardiac Metabolic Diseases .

Keywords
MicroRNA -Metabolic Syndrome (Diabetes-Hypertension-Hyperlipidemia-Obesity) Heart -Eye-Inflammation.

Environment
Cardiovascular Research Institute Maastricht, with excellent research groups within the microRNA field, including Leon de Windt, Blanche Schroen and Stephane Heymans, all grouped together within the department of Cardiology.

Project
The aim of the project is to discover novel microRNAs implicated in heart failure induced by the metabolic risk factors (hypertension, diabetes, hyperlipidemia), unravel their biological role, and study their therapeutic prospects for treating metabolic risk induced diseases, with a particular focus on heart failure and ocular diseases. Methods include, omics, bioinformatics, rodent experiments and molecular work.

This project is a collaborative project (exchange of people) between Maastricht University (Netherlands), Santaris Pharma (MicroRNA medicines, Denmark) and Omics/bioinformatical centre (GIGA, Liège, Belgium).

Functie-eisen

Highly competitive researcher, high impact articles, international network. Social, and able to lead and mentor 2 PhD students implicated in this project.
Experience in microRNA research, target analysis & upstream regulation, rodent experiments and related molecular work is requested.

Arbeidsvoorwaarden

Dienstverband: Temporary, 2 years

Organisatie

http://www.maastrichtuniversity.nl/

Meer informatie over de werkgever Maastricht University (UM) op AcademicTransfer. Verkorte link naar deze vacature: www.academictransfer.com/12315

Found here: http://www.academictransfer.com/employer/UM/vacancy/12315/lang/en/

Introduction of the ‘European Blue Card’

As from 19 June 2011 the Netherlands has a new purpose of stay: the European Blue Card. The European Blue Card is a separate purpose of stay in addition to the existing National Highly Skilled Migrant Programme. The EU Blue Card Council Directive is intended for highly skilled foreign nationals who do not have EU, EEA or Swiss nationality, and who wish to work in one of the member states of the EU. The Directive is also meant to make it easier to settle in another EU member state. A residence permit will always be required in that other member state, however. To obtain this residence permit the employee must comply with the conditions applicable in that member state.

The conditions for residence in the Netherlands as an EU Blue Card holder are stricter than those for residence as a Highly Skilled Migrant. The employee must have a contract for highly qualified employment for at least one year, earning at least EUR 60,000 gross (in 2011). The employee must have completed a course of higher education lasting at least three years. The employee must prove this by having his diploma assessed by Nuffic. For a regulated profession, a competent authority will take decisions about the admission to that profession.

Advantages
One of the advantages of the EU Blue Card is that it is easier for an EU Blue Card holder and his family members to settle in another EU member state at a later date. After eighteen months foreign nationals who have an EU Blue Card are exempted from the provisional residence permit (MVV) requirement, if they want to work in another EU member State. In this second member state the employee must submit an application for a residence permit as a holder of an EU Blue Card. Each member state may implement the directive in slightly different ways. If someone holds a Blue Card in the Netherlands, this does not mean that the requirements are also met in other member states.

Another advantage is that after having stayed lawfully with the EU Blue Card holder in the Netherlands for two years, the family members may apply for a residence permit for ‘continued residence’. For other purposes of stay this is only possible after having stayed lawfully in the Netherlands for three years. The family members must have resided legally and continuously within the territory of an EU member state for at least five years, however. An employee who has stayed legally in the Netherlands as an EU Blue Card holder for two years may apply for the status of ‘long-term resident as a non-EU member country national’. He must have resided legally and continuously within EU territory for five years and must comply with the other conditions for this purpose of stay.

Highly skilled migrants from outside of the EU

A highly skilled migrant is a migrant who comes to the Netherlands to be employed, and has a gross annual income of at least €47,565, or €34,881 if he/she is under thirty. This income requirement does not apply if the employee enters service for certain functions in an educational or research institution. For information on the specific functions to which this clause applies, you can inquire at the IND office for labour and highly skilled migrants. When a foreign national has been granted residence in the Netherlands as a highly skilled migrant, the employer of the highly skilled migrant is not required to be in possession of a work permit for that foreign national.

Professional soccer players, ministers of religion, teachers of religion and prostitutes are not eligible for a residency as highly skilled migrant.

Important!
The amounts stated above will be indexed every year as of 1 January.