VACANCY: Postdoc “Novel Anticancer Targets for Killing Drug Resistant Breast Tumor Cells”

Faculteit der Wiskunde en Natuurwetenschappen

Leiden Academic Center for Drug Research

The Leiden Academic Center for Drug Research (LACDR) is part of the Faculty of Science. The LACDR is a leading institute, which performs fundamental and strategic scientific research in the field of innovative drug research.
The division of Toxicology is part of the LACDR. The mission of the division is to understand the signal transduction networks in cancer development, progression and treatment with the ultimate aim to develop better and safer anticancer therapies. A focus of the division is on understanding the mechanisms that underlie drug resistance in breast cancer using synthetic lethality screening approaches.
The division of Toxicology is looking for a;
Postdoc “Novel Anticancer Targets for Killing Drug Resistant Breast Tumor Cells” (38 hours per week) Vacancynumber 13-132
Project Description
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer that has a poor disease prognosis. These tumors lack estrogen receptor (ER), progesterone receptor (PgR) and epidermal growth factor receptor 2 (HER2), and lack all receptors for which there are currently in breast cancer targeted agents available. Patients with TNBC are still treated with non-specific toxic chemotherapeutic drugs such as anthracycline and/or taxane-based chemotherapy. Newly developed targeted (combination) therapies are urgently needed for this heterogeneous subgroup of breast cancer patients. Genomics analysis of TNBC has identified various gene products that are associated with poor disease prognosis, yet their role in drug resistance is unclear. This project will involve a systematic RNA interference-based knock down screen of candidate modulators of drug resistance. We will use a small representative panel of human TNBC cell lines for synthetic lethality screens to identify novel drugable targets that can sensitize TNBC to common anticancer drugs. High content imaging-based approaches will be used. The role and mechanism of candidate genes will be studied in further detail in relation to DNA damage responses and/or mechanisms of cell death using molecular cell biology approaches. This project is a direct collaboration with the department of Medical Oncology at the Erasmus MC supporting the translation of the in vitro findings to the patient.

Requirements

We seek a talented and highly motivated candidate with proven experience in cell and molecular biology, cell signalling and cellular imaging. The candidate should have a PhD degree in the area of Oncology or Molecular Cell Biology and have demonstrated experience with screening and (breast) cancer. Experience or affinity with bioinformatics and cellular imaging is highly recommended.

We offer

The candidate will work within the Leiden Cell Observatory using state-of-the-art high content screening equipment. We are situated in the Gorlaeus Laboratories on the Science Park Leiden. Currently, 25 researchers including technicians, PhD students, and Postdocs work in the Division of Toxicology. The candidate will become part of a young and dynamic team with a strong expertise in cancer research and signal transduction. We offer a vibrant, research-driven work environment with emphasis on team spirit, excellence, and skills development.
Appointment will be according to the terms of the Collective Labour Agreement of Dutch Universities (CAO Nederlandse Universiteiten), for the duration of one year. An extension of two years after positive evaluation is possible. The function is validated in the University Function Ordening system (UFO) under the profile “Onderzoeker 4”. The salary will be set, depending on education and work experience, between the gross minimum of € 2403,- and gross maximum of € 3793,- per month, based on fulltime employment (salary scale: 10). Leiden University offers an attractive benefits package which includes an end-of-year premium of 8.3%, opportunities for personal development and possibilities for ‘personalized’ benefits via our Cafeteria model. More information about employment at Leiden University can be found at: www.leidenuniv.edu.

Information

For more information, please contact Prof.dr. Bob van de Water; telephone: +31-(0)71 527 6223; email: water_b@lacdr.leidenuniv.nl
Additionally, you can visit the websites of the Division of Toxicology, the Faculty of Science, and the LACDR: toxicol.lacdr.gorlaeus.net; www.science.leidenuniv.nl; www.lacdr.nl.

Applications

Do you identify with the profile above and aspire a career in bioscience? Please apply by sending your written application, full Curriculum Vitae and two letters of reference before May 13th, 2013 to the attention of Prof. dr. Bob van de Water.
Please follow this link to our application site; http://jobs.lacdr.leidenuniv.nl/2013/lacdrpd1

Found here: http://www.werkenbij.leidenuniv.nl/vacatures/wetenschappelijke-functies/13-132-postdoc-novel-anticancer-targets-for-killing-drug-resistant-breast-tumor-cells-.html 

Vacancy Postdoc Pathology (organ-specific metastases in colorectal cancer)

Job Radboud University Nijmegen Medical Centre (RUN MC) - Postdoc Pathology

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Postdoc Pathology

Specifications - (explanation)

Location	Nijmegen
Function types	Postdoc positions
Scientific fields	Health
Hours	36.0 hours per week
Education	Doctorate
Translations	en

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Job description

We have a vacancy for a post-doctoral fellow within a research program focusing on the identification of molecular factors that guide organ-specific metastases in colorectal cancer. While prognosis of patients with colorectal cancer has improved remarkably over the past decades, metastatic disease is the cause of death in a majority of colorectal cancer patients. Over the years many models have been developed to explain the metastatic process in detail, however, the molecular basis is still poorly understood. Recently, we have identified genetic aberrations in primary tumors that are involved in liver-specific metastases. Follow-up studies revealed specific high level amplifications involved in the development of metastatic disease. Unique patient series in combination with high quality molecular research will enable us to increase our knowledge within the next years.  The aim of the current project is to unravel the molecular processes and networks underlying organ-specific metastasis. The experimental work will be performed in collaboration with the Nijmegen Laboratory for Tumor Genetics.
The post-doctoral scientist:

• designs and performs scientific  research
• writes grant applications
• performs molecular techniques (PCR, qPCR, ion torrent, sequencing)
• performs situ hybridization techniques

Requirements

The post-doctoral scientist will primarily be recruited on the basis of scientific background and reputation and should be able to advance and complement the group’s present research program. We are looking for a creative and innovative scientist. Molecular and cellular biological expertise is required. Expertise with large scale genomic analyses and affinity with functional studies is preferred.

Conditions of employment

Temporary, after the first year, a positive evaluation of the postdoc can lead to an extension to a maximum of 3 years in total.

Organisation

Radboud University Nijmegen Medical Centre (RUN MC)

Nijmegen www.umcn.nl/ UMC St Radboud
Radboud University Nijmegen Medical Centre (RUN MC) is a leading academic centre for medical science, education and health care. Knowledge forms the heart of our organisation, connecting research, education and patient care. Over 10,000 staff and 3,500 students are committed and ambitious to contribute to the future of health care and medical science.
Driven by knowledge, empowered by people.

Department

Pathology

Radboud University Nijmegen Medical Centre (RUN MC) is a leading academic centre for medical science, education and health care. Knowledge forms the heart of our organisation, connecting research, education and patient care. Over 10,000 staff and 3,500 students are committed and ambitious to contribute to the future of health care and medical science. The research of the department of Pathology is embedded in the RUNMC Research Institute for Oncology and the Nijmegen Centre of Molecular Life Sciences (NCMLS).

Additional information

For more information about this position you can contact Dr. Iris Nagtegaal, T 0032 (0)24 3610229.

More information about employer Radboud University Nijmegen Medical Centre (RUN MC) on AcademicTransfer. Direct link to this job opening: www.academictransfer.com/16334

VACANCY: 2 PhD-students biological treatment planning in radiotherapy and hyperthermia

Job AMR - 2 PhD-students biological treatment planning in radiotherapy and hyperthermia

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2 PhD-students biological treatment planning in radiotherapy and hyperthermia

Specifications - (explanation)

Location	AMSTERDAM
Function types	Research, Development, Innovation
Scientific fields	Health
Hours	36.0 hours per week
Education	University Graduate
Job number	50054612-ACT-NL-031017
Translations	en

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Job description

Hyperthermia is the application of elevated temperatures (41-45°C) to tumour tissue and is applied in combination with radiotherapy and/or chemotherapy to improve tumour control. Hyperthermia can be administered before, during or after radiotherapy/chemotherapy. The sensitizing effect of hyperthermia depends on both the realized tumor temperatures and the order of application. In the hyperthermia community there is no univocal policy about the sequence of radiotherapy and hyperthermia and different institutes apply different treatment schemes. This research project “Towards biological treatment planning in radiotherapy combined with hyperthermia to improve clinical outcome” aims to find the optimal order of application of radiotherapy and hyperthermia and thereby further improve the effectiveness of clinical hyperthermia. This will be investigated using sophisticated treatment planning computer models, in which the combined effect of hyperthermia and radiotherapy is modeled. For accurate modeling knowledge about biological tissue parameters is necessary, which will be obtained from cell line and animal experiments for combined treatments with radiotherapy and hyperthermia.

Requirements

For this project we have vacancies for two highly motivated PhD candidates. One of them will carry out the cell line and animal experiments and the other candidate will perform the computer modeling part of the project. Candidate 1 should have an MSc degree in (medical) biology or a related background. The candidate should have good command of English. Excellent communicative skills and the ability to work within a multidisciplinary research group are essential. The research will involve in vitro and animal experiments. Candidate 2 should have an MSc degree in physics or a related background. The candidate should have good command of English. Excellent communicative skills and the ability to work within a multidisciplinary research group are essential. Programming experience in C/C++ is recommended.

Conditions of employment

We offer a salary in line with the Collective Labour Agreement for University Medical Centres in the Netherlands (CAO UMC) with a range of added fringe benefits, such as an annual bonus of 8.3 %, holiday allowance, collective discounted rates for a number of insurances, an attractive bicycle scheme and/or public transport allowance and free parking!
The PhD candidates will be appointed in a full-time position (36 hours/week) for a period of four years and at the end each PhD candidate should have completed his/her PhD thesis. Gross monthly salary for PhD candidates range from € 2.141,- gross per month in the first year up to € 2.743,- gross per month in the fourth year.
For more information please contact dr. Petra Kok, Physicist/Computer Scientist, or dr. Klaas Franken, Radiobiologist +31 (0)20 56 64231.

Contract type: Temporary,

Organisation

AMR

The AMC is more than just a hospital. It is a world in which patient care, research and education are integrated, and in which people are always central. It is an academic world full of possibilities for talented individuals that are looking for a place where they can excel. Thinking big, daring to dream, cooperating internationally. And never letting yourself be put off by ‘It’s not possible’ or ’It won’t work anyway’. That is the AMC mentality.

AMC Medical Research supports financiers, project leaders and coworkers on clear, effective and Legal execution of medical research within the Academic Medical Center (AMC) third parties financed. It contains advising and guidance on project preparations, project services and staffing management.

As a temporary researcher you will be contracted by AMC Medical Research. The related AMC department which you will service is physically your workplace. Working directly with your supervisor and your colleagues within your expertise or institution will be the base for your content job, your daily management and your working environment. The AMC Medical Research BV general employment conditions are largely similar to those of Academic Medical Center.

More information about employer Academic Medical Center (AMC) on AcademicTransfer. Direct link to this job opening: www.academictransfer.com/15717

Bron: http://www.academictransfer.com/employer/AMC/vacancy/15717/lang/en/

VACANCY: Postdoc determining radiation dose distribution for radiotherapy

Job Erasmus MC - Postdoc for the department of Radiotherapy - Mathematical Optimization of Cancer Treatment

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Postdoc for the department of Radiotherapy - Mathematical Optimization of Cancer Treatment

Specifications - (explanation)

Location	Rotterdam, 3015 CE, The Netherlands
Function types	Postdoc positions, Research, Development, Innovation
Scientific fields	Health
Hours	36.0 hours per week
Education	Doctorate
Job number	27.03.12.TDdH
Translations	en

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Job description

Approximately 50% of cancer patients is treated with radiotherapy. Success of a radiation treatment is largely determined by the quality of the delivered dose distribution. Doses should be very high in the tumor and as low as possible in surrounding healthy tissues, especially in vital radiation sensitive organs. Development of algorithms and procedures for design of individualized irradiation strategies (treatment plans) is a key research line of the department. Optimization of the patient’s dose distribution is a complex, non-convex and discrete mathematical problem with multiple objectives and constraints, and a patient anatomy that may change during the fractionated therapy. Not only the quality of the final dose distribution is important, but also optimization time, speed of daily dose delivery and required human interaction and workload. The selected candidate will participate in these investigations.

Requirements

• PhD in operations research, numerical mathematics, or other relevant field;
• Excellent programming skills (Python, C++, Matlab) for prototyping;
• Ambitious and eager to take initiative;
• Creative and excellent analytical skills;
• Ability to work in a multi-disciplinary team.

Conditions of employment

We offer a full-time position for a period of 3 years in an exciting working environment, aiming at improvement of patient care. The salary will depend on relevant experience and the job conditions are according to the Collective Bargaining Agreement for University Medical Centers (CAO UMC).

Contract type: Temporary, 3 years

Organisation

Erasmus MC

Erasmus MC inspires and is challenging. You create your own opportunities in this University Medical Center. Whether it concerns learning and work or work and learning/continued learning. Each and every day our enthusiastic staff devote themselves to excellent, dedicated patient care, pioneering medical research and valued education. A conscious choice for work that matters, both nationally and internationally, at the heart of our multicultural home base ofRotterdam. Where attention to individual staff member comes naturally. Working from the heart. Together with people, for people: ‘patient-centered care’!

Department

Radiotherapy

The Erasmus MC-Daniel den Hoed Cancer Center encompasses one of the largest radiation oncology departments in Europe treating 5000 patients per year. The departement has a wide-ranged and internationally renowned research program. Physics is of major importance in the program and a large part of the 50 employees of the Medical Physics division is involved in research projects. The department is equipped with state-of-the-art technologies and an extensive R&D software framework. Apart from computer optimization, image-guided and adaptive treatment, robotic treatment, stereotactic treatment, and proton therapy are among the main research lines. The department participates in the Holland Particle Therapy Center (HollandPTC) project. Research is embedded in multi-disciplinary teams, consisting of radiation oncologists, (medical) physicists, radiation technologists, mathematicians, and computer scientists.

Additional information

For more information, please contact Prof.dr. B.J.M. Heijmen, head of physics, telephone (+31) (0) 10 7041304, e-mail: b.heijmen@erasmusmc.nl, Ir. S. Breedveld, project leader, telephone (+31) (0) 10 7042693, e-mail: s.breedveld@erasmusmc.nl, or Drs. M.J. de Bruin, head of operations, telephone (+31) (0) 10 7041480, e-mail: m.j.debruin@erasmusmc.nl. More information on the R&D program can be found at: www.ncbi.nlm.nih.gov/pubmed?term=heijmen%20b*.

More information about employer Erasmus MC (University Medical Center Rotterdam) on AcademicTransfer. Direct link to this job opening: www.academictransfer.com/14749

VACANCY: PhD students for research in medical image analysis for personalised breast screening

Specifications - (explanation)

Location	Nijmegen
Function types	PhD positions
Scientific fields	Health, Computer Science, Physics, Engineering or Biomedical Sciences or similar
Hours	36.0 hours per week
Education	University Graduate
Translations	en

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Job description

Currently, breast screening is almost exclusively performed with mammography, even though it is known that some women are at a much higher risk to develop breast cancer or have dense breasts, in which sensitivity of mammography for detecting cancer is low (<60%). The aim of this project is to develop methods to personalise breast cancer screening. Firstly, reproducible quantitative markers characterizing breast density patterns in mammograms will be investigated and these will be related to the risk of developing breast cancer and the risk of missing a cancer with mammography. Secondly, techniques will be developed to increase feasibility of automated breast ultrasound imaging in women with dense breasts. These will include automated image analysis methods for computer aided decision support and advanced visualisation tools to combine ultrasound and mammography, or to compare screening exams over time. Research will be carried out in a large EU funded consortium in which ten partners cooperate.

Requirements

• You should be a creative and enthusiastic researcher with an MSc degree in Computer Science, Physics, Engineering or Biomedical Sciences or similar
• Interest in medical imaging and affinity with biomedical research
• Excellent communication skills in English, both writing and speech
• Expertise in software development, preferably in C++

Conditions of employment

• Schale 10A: max € 38090 gross per year at full employment
• Closing 15-08-2012

You will be appointed as a PhD student at the Radboud University Medical Center Nijmegen, department of Radiology, with the standard salary and secondary conditions for PhD students in the Netherlands. Your performance will be evaluated after 1 year. If the evaluation is positive, the contract will be extended by 3 years. The research should result in a PhD thesis.

Organisation

Radboud University Nijmegen Medical Centre (RUN MC)

Nijmegen www.umcn.nl/ UMC St Radboud
Radboud University Nijmegen Medical Centre (RUN MC) is a leading academic centre for medical science, education and health care. Knowledge forms the heart of our organisation, connecting research, education and patient care. Over 10,000 staff and 3,500 students are committed and ambitious to contribute to the future of health care and medical science.
Driven by knowledge, empowered by people.

Department

Radiology

The project will be carried out in the Diagnostic Image Analysis Group (DIAG) at the department of Radiology. DIAG investigates and develops computer aided diagnosis methods to support clinicians in a broad range of medical imaging applications. Research topics include image analysis, image segmentation, machine learning, and the design of decision support systems. Application areas include breast, prostate, and lung imaging. Key to the success of the group is close cooperation with clinical partners and a disease oriented approach. Currently the group consists of 35 researchers, including 20 PhD students.

Additional information

For further information please contact Prof. Nico Karssemeijer (n.karssemeijer@rad.umcn.nl) or Dr. Bram Platel (b.platel@rad.umcn.nl). Use these email adresses only for information, for application use the apply button.

More information about employer Radboud University Nijmegen Medical Centre (RUN MC) on AcademicTransfer. Direct link to this job opening: www.academictransfer.com/15054

Bron:  http://www.academictransfer.com/employer/UMCR/vacancy/15054/lang/en/

VACANCY: PhD Student at the Institute for Biology

Specifications - (explanation)

Location	Gorlaeus laboratories Einsteinweg 55 2333 CC Leiden
Function types	PhD positions
Scientific fields	Natural Sciences, Health
Hours	38.0 hours per week
Salary	maximum € 2612
Education	University Graduate
Job number	12-169
Translations	en

Apply for this job within 35 days

Job description

Tumors often display altered metabolic characteristics that are exclusive to the cancer cells and thus, can be targeted for efficient treatment.
The zebrafish is emerging as a valid model to study processes underlying cancer and provides an ideal setting to conduct chemical genetic screens for synthetic lethal interactions in the intact organism.
The tumor suppressor LKB1 is mutated in a familial cancer-predisposition syndrome and in over 30% of lung adenocarcinomas, one of the most common human tumors with a very poor prognosis. LKB1 is a serine-threonine kinase that phosphorylates the AMP-activated protein kinase (AMPK), a key energy checkpoint in the cell. AMPK activation leads to growth suppression through several pathways including inhibition of the mTOR pathway. Human tumors with LKB1 mutations exhibit fast metabolic rate, increased invasiveness and poor prognosis. We have recently shown that Lkb1 is critical to maintain energy homeostasis in zebrafish. lkb1 zebrafish mutants are embryonic-viable (in contrast to mice), exhibit deregulated metabolism and fast metabolic rate, a characteristic of tumors cells.
We will use our lkb1 zebrafish model as a discovery platform in chemical genetic synthetic-lethal screens and to resolve the LKB1 network in control of metabolism.

Requirements

You must be a motivated enthusiastic researcher with a degree (drs./MSc) in the domain of Biomedical Sciences and/or related subject and have a strong interest in the fields of Developmental biology, cancer biology, molecular genetics. You have demonstrated a strong interest in an academic career through your publication record and prior engagement in collaborative research and teaching. Furthermore you have excellent communication skills in English, both written and verbal and are expected to master the Dutch language sufficiently.

Conditions of employment

We offer a vibrant environment to develop on-the-job the skills and networks that a successful academic needs.
Appointment will be according to the terms of the Collective Labour Agreement of Dutch Universities (CAO Nederlandse Universiteiten), for a period of one year with an extension of three years after positive evaluation of capabilities and compatibility. Ultimately the appointment must lead to a completion of a PhD thesis. During your appointment you will be supervised by Dr. Anna-Pavlina Haramis as your co-promotor.
The gross monthly salary is set on € 2042,- in the first year up to € 2612,- in year four. An appointment with Leiden University includes a pension build-up and facilitates other benefits such as an annual holiday premium of 8% and an end-of-year premium of 8.3%.
All our PhD students are embedded in the Leiden University Graduate School of Science www.graduateschools.leidenuniv.nl and the Research School Functional Ecology. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness. In addition, advanced courses to deepen scientific knowledge are offered by the research school.

Organisation

Leiden University

Leiden is a typical university city, hosting the oldest university in the Netherlands (1575). The University permeates the local surroundings; University premises are scattered throughout the city, and the students who live and study in Leiden give the city its relaxed yet vibrant atmosphere.
Leiden University is one of Europe's foremost research universities. This prominent position gives our graduates a leading edge in applying for academic posts and for functions outside academia.

Additional information

The Faculty of Science of Leiden University focuses on excellent research and education in all its different disciplines. The overall theme of our faculty is our motto ‘Life Meets Science’. We stimulate multidisciplinary collaboration in the area of Bio-Sciences and are thus closely connected to the LUMC and Delft University of Technology. The Leiden University Faculty of Science is an inspiring place for state-of –the-art research and top quality education. Ambition, team spirit and dedication are at the heart of our success.
The Institute for Biology Leiden (IBL)
The Institute of Biology (IBL) is part of the Faculty of Science. It is located at the Leiden Bioscience Park in the recently completely refurbished Sylvius building, providing state-of-the-art facilities for biological research. It collaborates with neighboring institutes such as the Leiden University Medical Centre, the National Centre for Biodiversity Naturalis, the Centre for Environmental Sciences and the Leiden Institute of Chemistry. The IBL unites two research clusters with staff focusing on the Molecular Biosciences and Evolutionary Biosciences, respectively. The Institute has a long tradition of excellence in fundamental research in a broad range of biological subjects. It fosters an international atmosphere with strong interactions among the various groups as well as with other departments from the Faculty of Science and other partners. The IBL contributes to the Faculty priority area ‘Bioscience: the Science Base of Health’. To strengthen its profile in this area, the Institute invites applicants that can contribute to the Institute’s theme: ‘Healthy Lives in a Changing Environment’.
For more information, please contact Dr. Anna-Pavlina Haramis:
Telephone: +31-(0)71 5274782,  email: a.haramis@biology.leidenuniv.nl.
Additionally, you can visit the websites of the Faculty of Science and IBL: www.science.leidenuniv.nl and www.science.leidenuniv.nl/index.php/ibl/haramis.
More information about employment at Leiden University can be found via: www.leiden.edu.

VACANCY: Postdocs PhDs: Computational Analysis of NGS data

06-21-2012

Vacancy number 21

PROJECT OUTLINE

Genomic alterations are major determinant of responses to (targeted) therapies in cancer. In fact, the best positive and negative predictors of responses to targeted therapies are alterations in kinases or their direct downstream effectors. To gain insight into resistance mechanisms to therapy and thus better tailor treatment, we are approaching this problem from two different angles. First we have transplanted tumors from mouse models of breast cancer and treated these tumors with a range of (targeted) therapies. Matched pre- and post treatment pairs of resistant and sensitive tumors have been full exon sequenced and are available for analysis. The goal is to detect genomic alterations associated with response to therapy. Second, we have acquired large panels of human tumors, on which we are currently performing kinase exon sequencing. More specifically, we are performing sequencing on 1) 400 samples from the NEO-ALTTO study to find alterations associated with resistance to HER2 targeted therapies; 2) at least 200 colorectal samples and 300 breast cancers (triple negatives and invasive lobular carcinomas) to detect alterations frequently occurring in these patient populations. A very strong feature of all these datasets is that matched controls are available to ensure high accuracy in variant calling. The successful candidates will work closely with the biological groups to develop computational approaches for the detection of mutations and copy number alterations associated with specific cancer subtypes as well as therapy response in human and mouse model-derived tumors.

CANDIDATE REQUIREMENTS – EDUCATION AND EXPERIENCE

We are seeking highly motivated Postdoc and PhD candidates with a degree in bioinformatics or a mathematical discipline with a strong cancer biological interest. Applicants should either have strong modeling/applied statistics skills or strong documented experience in analyzing high-throughput sequencing data. In addition, we strongly value experience in one or more of the following: sequence analysis, machine learning, applied statistics and R, computer science and expression analysis. The candidate also needs to be proficient in a programming language such as Java, Perl or Python, and be comfortable with Linux systems. Fluency in spoken and written English is a strong requirement.

LOCATION

The project will employ the complementary expertise and tools of three groups participating in the Cancer Systems Biology Center (csbc.nki.nl) at the Netherlands Cancer Institute, Amsterdam: Rene Bernards (Molecular Carcinogenesis), Jos Jonkers (Mouse Models for Breast Cancer) and Lodewyk Wessels (Computational Biology). The positions are primarily embedded within the Bioinformatics and Statistics Group (Wessels) (bioinformatics.nki.nl) at the Netherlands Cancer Institute, Amsterdam.

EMPLOYMENT CONDITIONS

The successful candidate will be employed by the Netherlands Cancer Institute. Postdocs will be appointed for a period of 3 years. The gross salary per month will be from € 3.200,- to € 4.095,- according to the FWG-function group 55 or 60, depending on proven qualities and previous experience. PhDs will be employed by the Netherlands Cancer Institute for a period of 4 years. The gross salary per month will be from € 2407,- to € 2964,- according to the PhD scales, depending on proven qualities and previous experience. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals).

WANT MORE INFORMATION?

Please contact Dr. Lodewyk Wessels, tel. +31 20 512 7987 or e-mail: l.wessels@nki.nl. Also see bioinformatics.nki.nl and csbc.nki.nl for further information.

INTERESTED?

Your application letter (including your resume, a list of publications and the names and addresses of at least two persons that can be approached for references) can be attached before January 15, 2012 to the application form on our website (see link below). After dispatch of the form you will receive a reaction as soon as possible.

 http://www.nki.nl/Research/Career/Vacancies/Default/Postdoc_PhDs_Computational_Analysis_of_NGS_data_2011_157.htm

Looks like they made a mistake in the letter. Expiration date cant be right

Vacancy: Ph.D. student Oncology

Ph.D. student m/f, vacancy number 2012/0224

Location	Utrecht, provincie Utrecht
Function types	PhD positions, Research, Development, Innovation
Scientific fields	Health
Hours	36.0 hours per week
Salary	maximum € 2700
Education	University Graduate
Job number	2012/0224
Translations	en

Job description

You will be working in the Laboratory of Experimental Oncology in a group led by Dr. S.M.A. Lens. Research focuses on understanding how faithful chromosome segregation is normally ensured and why this segregation process is perturbed in cancer cells. The project encompasses biochemical, molecular biological, and cell-imaging techniques. You will also enroll in the CGDB Ph.D. program of Utrecht University’s Graduate School of Life Sciences.

Requirements

You are an enthusiastic, motivated Ph.D. student with a master’s degree in (medical) biology or (bio)chemistry. You must eventually be able to carry responsibility for your own research project and be a team player. You should also be able to communicate your work to an international scientific audience. Experience with cell culture, microscopy, safe microbiological techniques and radioactive isotopes would be an advantage.

Conditions of employment

For this 100% post the maximum salary will be € 2.700,- per month. This will be a temporary appointment for 4 years. 

Contract type: Temporary, 4 years

Department

Headed by Prof. E. Voest and Prof. G. Kops, the Laboratory of Experimental Oncology is a dynamic research lab in the Department of Medical Oncology. The lab hosts several research groups working on different cancer-related topics, including chemotherapy resistance, cancer genome sequencing, and causes and consequences of chromosomal instability. The lab is multidisciplinary and international, which ensures scientific quality and a good atmosphere.

More information about employer University Medical Center Utrecht (UMC Utrecht) on AcademicTransfer. Direct link to this job opening: www.academictransfer.com/13812

How to apply: see here:  http://www.academictransfer.com/employer/UMCU/vacancy/13812/lang/en/

The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL) is looking for a fulltime Postdoc Molecular Genetics

Specifications - (explanation)

Location	Amsterdam, the Netherlands
Function types	Technical, Laboratory positions, Postdoc positions, Research, Development, Innovation
Scientific fields	Natural Sciences
Hours	36.0 hours per week
Salary	€ 3153 - € 4034
Education	Doctorate
Job number	AT 98
Translations	en

Apply for this job within 42 days

Job description

We want to design new intervention strategies for lung cancer. These are urgently needed in view of the burden of this cancer. Therefore, we have developed mouse models that closely mimic the different lung cancers observed in man. In these models we have identified the cell-of-origin of the various lung tumor subtypes and we now want to determine how the ontogeny and the associated specific mutations influence the tumor characteristics such as their response to therapy. We approach this with advanced genetic methods that enable us to instantly generate new tumor models. We are particularly interested in therapy resistance mechanisms. Insight in these mechanisms should lead to improved treatment modalities for these tumors
Recent relevant publications:
Sutherland, K.D., Proost, N., Brouns, I., Adriaensen, D., Song, J-Y., and Berns, A. (2011). Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung.  Cancer Cell 19, 254-64.
Calbo, J., van Montfort, E., Proost, N., van Drunen, E., Beverloo, H., Meuwissen, R., and Berns, A. (2011) A functional role for tumor cell heterogeneity in a mouse model of Small Cell Lung Cancer.  Cancer Cell, 19, 244-56.
Huijbers, I.J., Krimpenfort, P., Berns, A., and Jonkers, J. (2011). A chimeric approach for rapid validation of candidate genes and drug targets in established genetically engineered mouse models of cancer.  Bioassays 33, 701-710.
The work will be carried out in the group of Anton Berns  in the Division of Molecular Genetics at The Netherlands Cancer Institute (Amsterdam), which offers a dynamic and international working environment and state-of-the-art facilities.

Requirements

We seek a motivated and ambitious postdoc wishing to continue a successful scientific career. The ideal candidate should hold a PhD and have a strong background in mouse genetics, proven ability to conduct multidisciplinary research in a competitive field, and an excellent record of early achievements. Knowledge of molecular biology or bioinformatics is advantageous.

Conditions of employment

The temporary employment will be for a period of 3 years. The gross salary per month will be from € 3.153,- to € 4.034,- according to the FWG-function group 55-60, depending on proven qualities and previous experience. Foreigners may benefit from a tax reduction facility. We can assist you in finding housing and child daycare facilities in the area. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals). Apart from being a specialized institute and hospital with good working conditions and an excellent atmosphere, the NKI-AVL has also been listed in the top 10 of ‘Best Employers’ in 2011.

Contract type: Temporary, 3 years

Organisation

The Netherlands Cancer Institute (NKI-AVL)

The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital (NKI-AVL) covers all major areas of cancer research and has special interest in adoptive cell therapies, requiring close collaboration between clinical and basic scientists.

Additional information

For more information about available projects, please contact Prof. Anton Berns(e- mail: a.berns@nki.nl; phone +31 20 5121991).

More information about employer The Netherlands Cancer Institute (NKI-AVL) on AcademicTransfer. Direct link to this job opening: www.academictransfer.com/13342

Found here:  http://www.academictransfer.com/employer/NKI/vacancy/13342/lang/en/