English speaking vacancies in Holland: VACANCY: Postdoc “Novel Anticancer Targets for Killing Drug Resistant Breast Tumor Cells”

Monday 20 May 2013

VACANCY: Postdoc “Novel Anticancer Targets for Killing Drug Resistant Breast Tumor Cells”

Faculteit der Wiskunde en Natuurwetenschappen

Leiden Academic Center for Drug Research

The Leiden Academic Center for Drug Research (LACDR) is part of the Faculty of Science. The LACDR is a leading institute, which performs fundamental and strategic scientific research in the field of innovative drug research.
The division of Toxicology is part of the LACDR. The mission of the division is to understand the signal transduction networks in cancer development, progression and treatment with the ultimate aim to develop better and safer anticancer therapies. A focus of the division is on understanding the mechanisms that underlie drug resistance in breast cancer using synthetic lethality screening approaches.
The division of Toxicology is looking for a;
Postdoc “Novel Anticancer Targets for Killing Drug Resistant Breast Tumor Cells” (38 hours per week) Vacancynumber 13-132
Project Description
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer that has a poor disease prognosis. These tumors lack estrogen receptor (ER), progesterone receptor (PgR) and epidermal growth factor receptor 2 (HER2), and lack all receptors for which there are currently in breast cancer targeted agents available. Patients with TNBC are still treated with non-specific toxic chemotherapeutic drugs such as anthracycline and/or taxane-based chemotherapy. Newly developed targeted (combination) therapies are urgently needed for this heterogeneous subgroup of breast cancer patients. Genomics analysis of TNBC has identified various gene products that are associated with poor disease prognosis, yet their role in drug resistance is unclear. This project will involve a systematic RNA interference-based knock down screen of candidate modulators of drug resistance. We will use a small representative panel of human TNBC cell lines for synthetic lethality screens to identify novel drugable targets that can sensitize TNBC to common anticancer drugs. High content imaging-based approaches will be used. The role and mechanism of candidate genes will be studied in further detail in relation to DNA damage responses and/or mechanisms of cell death using molecular cell biology approaches. This project is a direct collaboration with the department of Medical Oncology at the Erasmus MC supporting the translation of the in vitro findings to the patient.

Requirements

We seek a talented and highly motivated candidate with proven experience in cell and molecular biology, cell signalling and cellular imaging. The candidate should have a PhD degree in the area of Oncology or Molecular Cell Biology and have demonstrated experience with screening and (breast) cancer. Experience or affinity with bioinformatics and cellular imaging is highly recommended.

We offer

The candidate will work within the Leiden Cell Observatory using state-of-the-art high content screening equipment. We are situated in the Gorlaeus Laboratories on the Science Park Leiden. Currently, 25 researchers including technicians, PhD students, and Postdocs work in the Division of Toxicology. The candidate will become part of a young and dynamic team with a strong expertise in cancer research and signal transduction. We offer a vibrant, research-driven work environment with emphasis on team spirit, excellence, and skills development.
Appointment will be according to the terms of the Collective Labour Agreement of Dutch Universities (CAO Nederlandse Universiteiten), for the duration of one year. An extension of two years after positive evaluation is possible. The function is validated in the University Function Ordening system (UFO) under the profile “Onderzoeker 4”. The salary will be set, depending on education and work experience, between the gross minimum of € 2403,- and gross maximum of € 3793,- per month, based on fulltime employment (salary scale: 10). Leiden University offers an attractive benefits package which includes an end-of-year premium of 8.3%, opportunities for personal development and possibilities for ‘personalized’ benefits via our Cafeteria model. More information about employment at Leiden University can be found at: www.leidenuniv.edu.

Information

For more information, please contact Prof.dr. Bob van de Water; telephone: +31-(0)71 527 6223; email: water_b@lacdr.leidenuniv.nl
Additionally, you can visit the websites of the Division of Toxicology, the Faculty of Science, and the LACDR: toxicol.lacdr.gorlaeus.net; www.science.leidenuniv.nl; www.lacdr.nl.

Applications

Do you identify with the profile above and aspire a career in bioscience? Please apply by sending your written application, full Curriculum Vitae and two letters of reference before May 13th, 2013 to the attention of Prof. dr. Bob van de Water.
Please follow this link to our application site; http://jobs.lacdr.leidenuniv.nl/2013/lacdrpd1

Found here: http://www.werkenbij.leidenuniv.nl/vacatures/wetenschappelijke-functies/13-132-postdoc-novel-anticancer-targets-for-killing-drug-resistant-breast-tumor-cells-.html

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Introduction of the ‘European Blue Card’

As from 19 June 2011 the Netherlands has a new purpose of stay: the European Blue Card. The European Blue Card is a separate purpose of stay in addition to the existing National Highly Skilled Migrant Programme. The EU Blue Card Council Directive is intended for highly skilled foreign nationals who do not have EU, EEA or Swiss nationality, and who wish to work in one of the member states of the EU. The Directive is also meant to make it easier to settle in another EU member state. A residence permit will always be required in that other member state, however. To obtain this residence permit the employee must comply with the conditions applicable in that member state.

The conditions for residence in the Netherlands as an EU Blue Card holder are stricter than those for residence as a Highly Skilled Migrant. The employee must have a contract for highly qualified employment for at least one year, earning at least EUR 60,000 gross (in 2011). The employee must have completed a course of higher education lasting at least three years. The employee must prove this by having his diploma assessed by Nuffic. For a regulated profession, a competent authority will take decisions about the admission to that profession.

Advantages
One of the advantages of the EU Blue Card is that it is easier for an EU Blue Card holder and his family members to settle in another EU member state at a later date. After eighteen months foreign nationals who have an EU Blue Card are exempted from the provisional residence permit (MVV) requirement, if they want to work in another EU member State. In this second member state the employee must submit an application for a residence permit as a holder of an EU Blue Card. Each member state may implement the directive in slightly different ways. If someone holds a Blue Card in the Netherlands, this does not mean that the requirements are also met in other member states.

Another advantage is that after having stayed lawfully with the EU Blue Card holder in the Netherlands for two years, the family members may apply for a residence permit for ‘continued residence’. For other purposes of stay this is only possible after having stayed lawfully in the Netherlands for three years. The family members must have resided legally and continuously within the territory of an EU member state for at least five years, however. An employee who has stayed legally in the Netherlands as an EU Blue Card holder for two years may apply for the status of ‘long-term resident as a non-EU member country national’. He must have resided legally and continuously within EU territory for five years and must comply with the other conditions for this purpose of stay.

Highly skilled migrants from outside of the EU

A highly skilled migrant is a migrant who comes to the Netherlands to be employed, and has a gross annual income of at least €47,565, or €34,881 if he/she is under thirty. This income requirement does not apply if the employee enters service for certain functions in an educational or research institution. For information on the specific functions to which this clause applies, you can inquire at the IND office for labour and highly skilled migrants. When a foreign national has been granted residence in the Netherlands as a highly skilled migrant, the employer of the highly skilled migrant is not required to be in possession of a work permit for that foreign national.

Professional soccer players, ministers of religion, teachers of religion and prostitutes are not eligible for a residency as highly skilled migrant.

Important!
The amounts stated above will be indexed every year as of 1 January.