PhD Student Ear-Nose-Throat Department
- Specifications - (explanation)
Location Nijmegen Function types PhD positions Scientific fields Health Hours 36.0 hours per week Education University Graduate Translations en
Job description
The
PhD student will perform research for the project entitled “The
zebrafish model as a tool for the gene therapy for retinal degeneration
caused by mutations in USH2A: new insights and treatment”, a grant from
Dutch foundations for eye disorders.
Both fundamental and translational research are part of the project. The researcher:
Defects in the USH2A gene are the most common cause of Usher syndrome (deafblindness) and an important cause of nonsyndromic retinal degeneration. The gene is too large for gene augmentation therapy with the currently available vectors. Therefore, alternative strategies will be developed to achieve (partial) gene function. Also, novel handles for therapeutic strategies will be sought by unraveling the function of the USH2A protein. Zebrafish will be employed as animal model for these studies.
Both fundamental and translational research are part of the project. The researcher:
- is part of a multidisciplinary team of researchers
- presents the results in scientific journals and on meetings
- takes part in the activities for graduate students of the Nijmegen Centre for Molecular Life Sciences and the Donders Institute for Brain, Cognition and Behaviour
Defects in the USH2A gene are the most common cause of Usher syndrome (deafblindness) and an important cause of nonsyndromic retinal degeneration. The gene is too large for gene augmentation therapy with the currently available vectors. Therefore, alternative strategies will be developed to achieve (partial) gene function. Also, novel handles for therapeutic strategies will be sought by unraveling the function of the USH2A protein. Zebrafish will be employed as animal model for these studies.
Requirements
MSc in biology, molecular life sciences or biomedical sciences
- Experience with molecular biological techniques
- Experience with zebrafish studie
- Team oriented and enthusiastic
Conditions of employment
Temporary 4 years
Maximum all-in yearly salary on full time basis is € 38,000 gross
Maximum all-in yearly salary on full time basis is € 38,000 gross
Organisation
Radboud University Nijmegen Medical Centre (RUN MC)
Nijmegen www.umcn.nl/ UMC St Radboud
Radboud University Nijmegen Medical Centre (RUN MC) is a leading academic centre for medical science, education and health care. Knowledge forms the heart of our organisation, connecting research, education and patient care. Over 10,000 staff and 3,500 students are committed and ambitious to contribute to the future of health care and medical science.
Driven by knowledge, empowered by people.
Radboud University Nijmegen Medical Centre (RUN MC) is a leading academic centre for medical science, education and health care. Knowledge forms the heart of our organisation, connecting research, education and patient care. Over 10,000 staff and 3,500 students are committed and ambitious to contribute to the future of health care and medical science.
Driven by knowledge, empowered by people.
Department
Department of Ear Nose and Throat ENT
The
department of Ear Nose and Throat (ENT) has a long-standing interest
in hereditary hearing loss and deafblindness (Usher syndrome) and is a
(inter)national reference centre for patients with hearing impairment.
World-leading scientific research in this field is being performed on
both the clinical and molecular aspects of the disorders. The Molecular
Otogenetics research group is housed in the department of Human Genetics
and is part of the Nijmegen Centre for Molecular Life Sciences (NCMLS)
and the Donders Institute for Brain, Cognition and Behaviour.
Additional information
For more information please contact dr. Hannie Kremer, Professor for molecular otogenetics, tel: +31 (0) 24-3614017, H.Kremer@gen.umcn.nl.
More information about employer
Radboud University Nijmegen Medical Centre (RUN MC)
on AcademicTransfer.
Direct link to this job opening: www.academictransfer.com/13601Apply here: http://www.academictransfer.com/employer/UMCR/vacancy/13601/lang/en/
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