Showing posts with label biological. Show all posts

Wednesday, 21 November 2012

Vacancy Postdoc Pathology (organ-specific metastases in colorectal cancer)

Job Radboud University Nijmegen Medical Centre (RUN MC) - Postdoc Pathology

Postdoc Pathology

Location	Nijmegen
Function types	Postdoc positions
Scientific fields	Health
Hours	36.0 hours per week
Education	Doctorate
Translations	en

Apply for this job within 4 days

Job description

We have a vacancy for a post-doctoral fellow within a research program focusing on the identification of molecular factors that guide organ-specific metastases in colorectal cancer. While prognosis of patients with colorectal cancer has improved remarkably over the past decades, metastatic disease is the cause of death in a majority of colorectal cancer patients. Over the years many models have been developed to explain the metastatic process in detail, however, the molecular basis is still poorly understood. Recently, we have identified genetic aberrations in primary tumors that are involved in liver-specific metastases. Follow-up studies revealed specific high level amplifications involved in the development of metastatic disease. Unique patient series in combination with high quality molecular research will enable us to increase our knowledge within the next years. The aim of the current project is to unravel the molecular processes and networks underlying organ-specific metastasis. The experimental work will be performed in collaboration with the Nijmegen Laboratory for Tumor Genetics.
The post-doctoral scientist:

designs and performs scientific research
writes grant applications
performs molecular techniques (PCR, qPCR, ion torrent, sequencing)
performs situ hybridization techniques

Requirements

The post-doctoral scientist will primarily be recruited on the basis of scientific background and reputation and should be able to advance and complement the group’s present research program. We are looking for a creative and innovative scientist. Molecular and cellular biological expertise is required. Expertise with large scale genomic analyses and affinity with functional studies is preferred.

Conditions of employment

Temporary, after the first year, a positive evaluation of the postdoc can lead to an extension to a maximum of 3 years in total.

Organisation

Radboud University Nijmegen Medical Centre (RUN MC)

Nijmegen www.umcn.nl/ UMC St Radboud
Radboud University Nijmegen Medical Centre (RUN MC) is a leading academic centre for medical science, education and health care. Knowledge forms the heart of our organisation, connecting research, education and patient care. Over 10,000 staff and 3,500 students are committed and ambitious to contribute to the future of health care and medical science.
Driven by knowledge, empowered by people.

Department

Pathology

Radboud University Nijmegen Medical Centre (RUN MC) is a leading academic centre for medical science, education and health care. Knowledge forms the heart of our organisation, connecting research, education and patient care. Over 10,000 staff and 3,500 students are committed and ambitious to contribute to the future of health care and medical science. The research of the department of Pathology is embedded in the RUNMC Research Institute for Oncology and the Nijmegen Centre of Molecular Life Sciences (NCMLS).

Additional information

For more information about this position you can contact Dr. Iris Nagtegaal, T 0032 (0)24 3610229.

More information about employer Radboud University Nijmegen Medical Centre (RUN MC) on AcademicTransfer. Direct link to this job opening: www.academictransfer.com/16334

Wednesday, 28 March 2012

Vacancy: Job Radboud University Nijmegen Medical Centre (RUN MC) - PhD Student Ear-Nose-Throat Department

PhD Student Ear-Nose-Throat Department

Specifications - (explanation)

Location	Nijmegen
Function types	PhD positions
Scientific fields	Health
Hours	36.0 hours per week
Education	University Graduate
Translations	en

Apply for this job within 20 days

Job description

The PhD student will perform research for the project entitled “The zebrafish model as a tool for the gene therapy for retinal degeneration caused by mutations in USH2A: new insights and treatment”, a grant from Dutch foundations for eye disorders.
Both fundamental and translational research are part of the project. The researcher:

is part of a multidisciplinary team of researchers
presents the results in scientific journals and on meetings
takes part in the activities for graduate students of the Nijmegen Centre for Molecular Life Sciences and the Donders Institute for Brain, Cognition and Behaviour

Additional information:
Defects in the USH2A gene are the most common cause of Usher syndrome (deafblindness) and an important cause of nonsyndromic retinal degeneration. The gene is too large for gene augmentation therapy with the currently available vectors. Therefore, alternative strategies will be developed to achieve (partial) gene function. Also, novel handles for therapeutic strategies will be sought by unraveling the function of the USH2A protein. Zebrafish will be employed as animal model for these studies.

Requirements

MSc in biology, molecular life sciences or biomedical sciences

Experience with molecular biological techniques
Experience with zebrafish studie
Team oriented and enthusiastic

Conditions of employment

Temporary 4 years
Maximum all-in yearly salary on full time basis is € 38,000 gross

Organisation

Radboud University Nijmegen Medical Centre (RUN MC)

Department

Department of Ear Nose and Throat ENT

The department of Ear Nose and Throat (ENT) has a long-standing interest in hereditary hearing loss and deafblindness (Usher syndrome) and is a (inter)national reference centre for patients with hearing impairment. World-leading scientific research in this field is being performed on both the clinical and molecular aspects of the disorders. The Molecular Otogenetics research group is housed in the department of Human Genetics and is part of the Nijmegen Centre for Molecular Life Sciences (NCMLS) and the Donders Institute for Brain, Cognition and Behaviour.

Additional information

For more information please contact dr. Hannie Kremer, Professor for molecular otogenetics, tel: +31 (0) 24-3614017, H.Kremer@gen.umcn.nl.

More information about employer Radboud University Nijmegen Medical Centre (RUN MC) on AcademicTransfer. Direct link to this job opening: www.academictransfer.com/13601

Apply here: http://www.academictransfer.com/employer/UMCR/vacancy/13601/lang/en/

Introduction of the ‘European Blue Card’

As from 19 June 2011 the Netherlands has a new purpose of stay: the European Blue Card. The European Blue Card is a separate purpose of stay in addition to the existing National Highly Skilled Migrant Programme. The EU Blue Card Council Directive is intended for highly skilled foreign nationals who do not have EU, EEA or Swiss nationality, and who wish to work in one of the member states of the EU. The Directive is also meant to make it easier to settle in another EU member state. A residence permit will always be required in that other member state, however. To obtain this residence permit the employee must comply with the conditions applicable in that member state.

The conditions for residence in the Netherlands as an EU Blue Card holder are stricter than those for residence as a Highly Skilled Migrant. The employee must have a contract for highly qualified employment for at least one year, earning at least EUR 60,000 gross (in 2011). The employee must have completed a course of higher education lasting at least three years. The employee must prove this by having his diploma assessed by Nuffic. For a regulated profession, a competent authority will take decisions about the admission to that profession.

Advantages
One of the advantages of the EU Blue Card is that it is easier for an EU Blue Card holder and his family members to settle in another EU member state at a later date. After eighteen months foreign nationals who have an EU Blue Card are exempted from the provisional residence permit (MVV) requirement, if they want to work in another EU member State. In this second member state the employee must submit an application for a residence permit as a holder of an EU Blue Card. Each member state may implement the directive in slightly different ways. If someone holds a Blue Card in the Netherlands, this does not mean that the requirements are also met in other member states.

Another advantage is that after having stayed lawfully with the EU Blue Card holder in the Netherlands for two years, the family members may apply for a residence permit for ‘continued residence’. For other purposes of stay this is only possible after having stayed lawfully in the Netherlands for three years. The family members must have resided legally and continuously within the territory of an EU member state for at least five years, however. An employee who has stayed legally in the Netherlands as an EU Blue Card holder for two years may apply for the status of ‘long-term resident as a non-EU member country national’. He must have resided legally and continuously within EU territory for five years and must comply with the other conditions for this purpose of stay.

Highly skilled migrants from outside of the EU

A highly skilled migrant is a migrant who comes to the Netherlands to be employed, and has a gross annual income of at least €47,565, or €34,881 if he/she is under thirty. This income requirement does not apply if the employee enters service for certain functions in an educational or research institution. For information on the specific functions to which this clause applies, you can inquire at the IND office for labour and highly skilled migrants. When a foreign national has been granted residence in the Netherlands as a highly skilled migrant, the employer of the highly skilled migrant is not required to be in possession of a work permit for that foreign national.

Professional soccer players, ministers of religion, teachers of religion and prostitutes are not eligible for a residency as highly skilled migrant.

Important!
The amounts stated above will be indexed every year as of 1 January.