English speaking vacancies in Holland: 2 PhD Students Tailored Treatment and systems biology of Chronic Heart Failure

Monday, 9 January 2012

2 PhD Students Tailored Treatment and systems biology of Chronic Heart Failure

Specificaties - (uitleg)

Functietypes	PhD positions
Wetenschappelijke discipline	Health
Uren	36.0 uren per week
Salaris	€ 2107 - € 2700
Werk-/denkniveau	Higher Professional Education +
Vacaturenummer	MR0329
Vertalingen	en

Solliciteer binnen 28 dagen op deze vacature

In Europe the prevalence of heart failure (HF) is about 10-20 in 1000 persons and the prevalence is rising due to the ageing European population. In persons over 75 years of age about 10% is affected. Despite major improvements in the last decennium, prognosis and quality of life of CHF patients is limited. One of the reasons is that response to pharmacological treatment varies between individuals. To investigate markers of treatment-response, 5000 HF patients will be followed in the BiOSTAT-CHF project for mortality, hospitalization and their quality of life. Demographic data, established biomarkers and new genomic and proteomic biomarkers will be combined in prognostic models to predict treatment-response. The BiOSTAT-CHF is an EU-funded project with collaborators from France, Greece, Germany, Italy, the Netherlands, Norway, Poland, and the UK (www.biostat-chf.eu).
Within this project there are two vacant positions for PhD students.
1. The primary aim of the first project is the development of prognostic models for the response to pharmacological treatment by CHF patients. The prognostic models concern mortality and morbidity of the patients and will be based on well known statistical methods using established risk factors of CHF as well as new biomarkers identified from genome-wide and proteome-wide biomarker identification. The prognostic models will be developed from the primary BiOSTAT-CHF sample and will be validated in a well characterized second sample.

2. The primary aim of the second project is the development of a systems biology approach to link the multidimensional clinical phenotypes of the CHF-patients and their outcome to genetic markers, gene transcription and translation levels in peripheral blood cells. Aim is to derive concise causal pathogenetic pathways that link the genetic and molecular data to the different CHF phenotypes and outcomes. For this project it is necessary to develop new statistical and bioinformatics methods.

Functie-eisen

We look for investigators with a master of science in medicine, biomedical/life sciences or (clinical) epidemiology (project 1) and investigators with a master of science in bioinformatics or mathematics/statistics (project 2). For both projects a very good command of the English language (spoken and in writing) is required because of frequent and intensive contacts with partners in the BiOSTAT-CHF project. Experience with clinical research and CHF is preferred but not a prerequisite. Candidates must be willing to travel to participating centers across Europe.

Arbeidsvoorwaarden

- A full time PhD position with the possibility to participate in the exiting BiOSTAT-CHF project and to write PhD-theses on developing future tools for personalized medicine and understanding molecular biological underpinnings of chronic heart failure.
- Employment by the AMC Medical Research foundation for a period of 12 months, with possible extension of the contract to 48 months.
- A gross salary will be € 2.107,00 per month in the first year, with an increase to the maximum of € 2.700,00 per month in the fourth year. In addition the AMR BV has an End of Year Bonus of 8.3% and a holiday payment of 8% of the gross yearly salary.
- As a PhD candidate, you are entitled to follow courses provided by the AMC Graduate School.

Dienstverband: Temporary, 12 months, with possible extension of the contract to 48 months

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Introduction of the ‘European Blue Card’

As from 19 June 2011 the Netherlands has a new purpose of stay: the European Blue Card. The European Blue Card is a separate purpose of stay in addition to the existing National Highly Skilled Migrant Programme. The EU Blue Card Council Directive is intended for highly skilled foreign nationals who do not have EU, EEA or Swiss nationality, and who wish to work in one of the member states of the EU. The Directive is also meant to make it easier to settle in another EU member state. A residence permit will always be required in that other member state, however. To obtain this residence permit the employee must comply with the conditions applicable in that member state.

The conditions for residence in the Netherlands as an EU Blue Card holder are stricter than those for residence as a Highly Skilled Migrant. The employee must have a contract for highly qualified employment for at least one year, earning at least EUR 60,000 gross (in 2011). The employee must have completed a course of higher education lasting at least three years. The employee must prove this by having his diploma assessed by Nuffic. For a regulated profession, a competent authority will take decisions about the admission to that profession.

Advantages
One of the advantages of the EU Blue Card is that it is easier for an EU Blue Card holder and his family members to settle in another EU member state at a later date. After eighteen months foreign nationals who have an EU Blue Card are exempted from the provisional residence permit (MVV) requirement, if they want to work in another EU member State. In this second member state the employee must submit an application for a residence permit as a holder of an EU Blue Card. Each member state may implement the directive in slightly different ways. If someone holds a Blue Card in the Netherlands, this does not mean that the requirements are also met in other member states.

Another advantage is that after having stayed lawfully with the EU Blue Card holder in the Netherlands for two years, the family members may apply for a residence permit for ‘continued residence’. For other purposes of stay this is only possible after having stayed lawfully in the Netherlands for three years. The family members must have resided legally and continuously within the territory of an EU member state for at least five years, however. An employee who has stayed legally in the Netherlands as an EU Blue Card holder for two years may apply for the status of ‘long-term resident as a non-EU member country national’. He must have resided legally and continuously within EU territory for five years and must comply with the other conditions for this purpose of stay.

Highly skilled migrants from outside of the EU

A highly skilled migrant is a migrant who comes to the Netherlands to be employed, and has a gross annual income of at least €47,565, or €34,881 if he/she is under thirty. This income requirement does not apply if the employee enters service for certain functions in an educational or research institution. For information on the specific functions to which this clause applies, you can inquire at the IND office for labour and highly skilled migrants. When a foreign national has been granted residence in the Netherlands as a highly skilled migrant, the employer of the highly skilled migrant is not required to be in possession of a work permit for that foreign national.

Professional soccer players, ministers of religion, teachers of religion and prostitutes are not eligible for a residency as highly skilled migrant.

Important!
The amounts stated above will be indexed every year as of 1 January.