Friday 9 March 2012

The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL) is looking for a fulltime Postdoc Molecular Genetics


Specifications - (explanation)
Location Amsterdam, the Netherlands
Function typesTechnical, Laboratory positions, Postdoc positions, Research, Development, Innovation
Scientific fieldsNatural Sciences
Hours 36.0 hours per week
Salary € 3153 - € 4034
EducationDoctorate
Job number AT 98
Translations
Apply for this job within 42 days

Job description

We want to design new intervention strategies for lung cancer. These are urgently needed in view of the burden of this cancer. Therefore, we have developed mouse models that closely mimic the different lung cancers observed in man. In these models we have identified the cell-of-origin of the various lung tumor subtypes and we now want to determine how the ontogeny and the associated specific mutations influence the tumor characteristics such as their response to therapy. We approach this with advanced genetic methods that enable us to instantly generate new tumor models. We are particularly interested in therapy resistance mechanisms. Insight in these mechanisms should lead to improved treatment modalities for these tumors
Recent relevant publications:
Sutherland, K.D., Proost, N., Brouns, I., Adriaensen, D., Song, J-Y., and Berns, A. (2011). Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung.  Cancer Cell 19, 254-64.
Calbo, J., van Montfort, E., Proost, N., van Drunen, E., Beverloo, H., Meuwissen, R., and Berns, A. (2011) A functional role for tumor cell heterogeneity in a mouse model of Small Cell Lung Cancer.  Cancer Cell, 19, 244-56.
Huijbers, I.J., Krimpenfort, P., Berns, A., and Jonkers, J. (2011). A chimeric approach for rapid validation of candidate genes and drug targets in established genetically engineered mouse models of cancer.  Bioassays 33, 701-710.
The work will be carried out in the group of Anton Berns  in the Division of Molecular Genetics at The Netherlands Cancer Institute (Amsterdam), which offers a dynamic and international working environment and state-of-the-art facilities.

Requirements

We seek a motivated and ambitious postdoc wishing to continue a successful scientific career. The ideal candidate should hold a PhD and have a strong background in mouse genetics, proven ability to conduct multidisciplinary research in a competitive field, and an excellent record of early achievements. Knowledge of molecular biology or bioinformatics is advantageous.

Conditions of employment

The temporary employment will be for a period of 3 years. The gross salary per month will be from € 3.153,- to € 4.034,- according to the FWG-function group 55-60, depending on proven qualities and previous experience. Foreigners may benefit from a tax reduction facility. We can assist you in finding housing and child daycare facilities in the area. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals). Apart from being a specialized institute and hospital with good working conditions and an excellent atmosphere, the NKI-AVL has also been listed in the top 10 of ‘Best Employers’ in 2011.
Contract type: Temporary, 3 years

Organisation

The Netherlands Cancer Institute (NKI-AVL)
The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital (NKI-AVL) covers all major areas of cancer research and has special interest in adoptive cell therapies, requiring close collaboration between clinical and basic scientists.

Additional information

For more information about available projects, please contact Prof. Anton Berns(e- mail: a.berns@nki.nl; phone +31 20 5121991).
More information about employer The Netherlands Cancer Institute (NKI-AVL) on AcademicTransfer. Direct link to this job opening: www.academictransfer.com/13342

Found here:  http://www.academictransfer.com/employer/NKI/vacancy/13342/lang/en/

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