English speaking vacancies in Holland: Diabetes

Showing posts with label Diabetes. Show all posts

Wednesday, 2 May 2012

VACANCY: PhD-student, FHML/School for Cardiovascular Diseases

PhD-student, FHML/School for Cardiovascular Diseases (CARIM)/vakgroep Interne Geneeskunde

Specificaties - (uitleg)

Locatie	Maastricht 6200 MD Limburg
Functietypes	PhD positions
Wetenschappelijke discipline	Health
Uren	38.0 uren per week
Salaris	€ 2042 - € 2612
Werk-/denkniveau	University Graduate
Vacaturenummer	AT2012.74
Vertalingen	en

Solliciteer binnen 11 dagen op deze vacature

Functiebeschrijving

The applicant will conduct research in the vascular research group of the dept. of Internal Medicine. This research is embedded in theme Vascular biology of the Cardiovascular Research Institute Maastricht (www.carim.unimaas.nl/).
A growing body of evidence demonstrates that increased adipose mass and the induced expression of adipokines contribute directly towards the burden of insulin resistance and the development of type 2 diabetes. We recently found that the accumulation of the advanced glycation/lipoxidation endproduct (AGEs/ALEs) N-(Carboxymethyl)lysine (CML) in the expanding adipose tissue and activation of the CML-RAGE axis in adipocytes is a novel mechanism contributing to the dysregulation of adipokines. Moreover, activation of the CML-RAGE axis decreased the expression of glyoxalase-1 i.e the enzyme detoxifying the main AGE precursor methylglyoxal (MG), in adipocytes. Our hypothesis is that inhibition of the accumulation of CML and formation of MG leads to amelioration of adipose-tissue derived adipokines and a decreased risk for the development of obesity-associated insulin resistance and type 2 diabetes. The main objectives of this study are to elucidate the association of CML and MG in adipose tissue with progression of insulin resistance and to elucidate whether intervention strategies to inhibit CML and MG accumulation are able to attenuate the development of insulin resistance. We will investigate whether intervention strategies to inhibit CML and MG accumulation are able to attenuate the impaired adipokine-profile in obesity and to improve insulin sensitivity (animal studies) and whether MGO and/or MGO-derived AGEs are directly involved in vascular insulin resistance/signaling (ex-vivo studies). The impact, from a clinical point of view, will be that this study will lead to new possibilities for intervention.

Functie-eisen

Degree in biology, biochemistry, medicine or health sciences. Experience with animal work is a prerequisite and possession of a Laboratory Animal license is an advantage. Subsequent to the PhD project, there will be the possibility for candidates with a degree in medicine of a residency program in Internal Medicine

Arbeidsvoorwaarden

The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website www.maastrichtuniversity.nl/, A-Z Terms of Employment.
Temporary employment for 4 years.
Your salary would be € 2.042,-- gross per month in the first year up to € 2.612,-- gross per month in the fourth year according to the PhD-student salary scale.
Each year an evaluation will take place.

Dienstverband: Temporary, 4 years

Organisatie

http://www.maastrichtuniversity.nl/

Maastricht University is renowned for its unique, innovative, problem-based learning system, which is characterized by a small-scale and student-oriented approach. Research at UM is characterized by a multidisciplinary and thematic approach, and is concentrated in research institutes and schools. Maastricht University has around 14,500 students and 3,800 employees. Reflecting the university's strong international profile, a fair amount of both students and staff are from abroad. The university hosts 6 faculties: Faculty of Health, Medicine and Life Sciences, Faculty of Law, School of Business and Economics, Faculty of Humanities and Sciences, Faculty of Arts and Social Sciences, Faculty of Psychology and Neuroscience.

Additionele informatie

For more information:
Prof Dr. C.G. Schalkwijk, Department of Internal Medicine
email C.Schalkwijk@Maastrichtuniversity.nl
tel: +31 43 3882186

Prof dr CDA Stehouwer, Department of Internal Medicine
email: cda.stehouwer@mumc.nl
tel: +31 43 3877006
For more information about the procedure
Ms M. Berghof
email: martine.berghof@maastrichtuniversity.nl
tel: +31 43 387 2835

Apply here: http://www.academictransfer.com/employer/UM/vacancy/13900/lang/en/

Tuesday, 20 December 2011

International post-doc position for microRNA therapeutic in heart failure induced by the metabolic risk

Specificaties - (uitleg)

Locatie	Maastricht 6200 MD Limburg
Functietypes	Postdoc positions
Wetenschappelijke discipline	Health
Uren	38.0 uren per week
Salaris	€ 2379 - € 3755
Werk-/denkniveau	Doctorate
Vacaturenummer	AT2011.179
Vertalingen	en

Solliciteer binnen 27 dagen op deze vacature

Functiebeschrijving

Position at the post-doctoral level for 2 years at the University of Maastricht, Cardiovascular Research Institute Maastricht, Cardiology Department.

Within European FP7 Marie Curie Work Programme coördinated by Prof.dr. S. Heymans, we are looking for an excellent, highly competitive researcher at the post-doc level.

Topic
Development of microRNA-medicines for Cardiac Metabolic Diseases .

Keywords
MicroRNA -Metabolic Syndrome (Diabetes-Hypertension-Hyperlipidemia-Obesity) Heart -Eye-Inflammation.

Environment
Cardiovascular Research Institute Maastricht, with excellent research groups within the microRNA field, including Leon de Windt, Blanche Schroen and Stephane Heymans, all grouped together within the department of Cardiology.

Project
The aim of the project is to discover novel microRNAs implicated in heart failure induced by the metabolic risk factors (hypertension, diabetes, hyperlipidemia), unravel their biological role, and study their therapeutic prospects for treating metabolic risk induced diseases, with a particular focus on heart failure and ocular diseases. Methods include, omics, bioinformatics, rodent experiments and molecular work.

This project is a collaborative project (exchange of people) between Maastricht University (Netherlands), Santaris Pharma (MicroRNA medicines, Denmark) and Omics/bioinformatical centre (GIGA, Liège, Belgium).

Functie-eisen

Highly competitive researcher, high impact articles, international network. Social, and able to lead and mentor 2 PhD students implicated in this project.
Experience in microRNA research, target analysis & upstream regulation, rodent experiments and related molecular work is requested.

Arbeidsvoorwaarden

Dienstverband: Temporary, 2 years

Organisatie

http://www.maastrichtuniversity.nl/

Meer informatie over de werkgever Maastricht University (UM) op AcademicTransfer. Verkorte link naar deze vacature: www.academictransfer.com/12315

Found here: http://www.academictransfer.com/employer/UM/vacancy/12315/lang/en/

Introduction of the ‘European Blue Card’

As from 19 June 2011 the Netherlands has a new purpose of stay: the European Blue Card. The European Blue Card is a separate purpose of stay in addition to the existing National Highly Skilled Migrant Programme. The EU Blue Card Council Directive is intended for highly skilled foreign nationals who do not have EU, EEA or Swiss nationality, and who wish to work in one of the member states of the EU. The Directive is also meant to make it easier to settle in another EU member state. A residence permit will always be required in that other member state, however. To obtain this residence permit the employee must comply with the conditions applicable in that member state.

The conditions for residence in the Netherlands as an EU Blue Card holder are stricter than those for residence as a Highly Skilled Migrant. The employee must have a contract for highly qualified employment for at least one year, earning at least EUR 60,000 gross (in 2011). The employee must have completed a course of higher education lasting at least three years. The employee must prove this by having his diploma assessed by Nuffic. For a regulated profession, a competent authority will take decisions about the admission to that profession.

Advantages
One of the advantages of the EU Blue Card is that it is easier for an EU Blue Card holder and his family members to settle in another EU member state at a later date. After eighteen months foreign nationals who have an EU Blue Card are exempted from the provisional residence permit (MVV) requirement, if they want to work in another EU member State. In this second member state the employee must submit an application for a residence permit as a holder of an EU Blue Card. Each member state may implement the directive in slightly different ways. If someone holds a Blue Card in the Netherlands, this does not mean that the requirements are also met in other member states.

Another advantage is that after having stayed lawfully with the EU Blue Card holder in the Netherlands for two years, the family members may apply for a residence permit for ‘continued residence’. For other purposes of stay this is only possible after having stayed lawfully in the Netherlands for three years. The family members must have resided legally and continuously within the territory of an EU member state for at least five years, however. An employee who has stayed legally in the Netherlands as an EU Blue Card holder for two years may apply for the status of ‘long-term resident as a non-EU member country national’. He must have resided legally and continuously within EU territory for five years and must comply with the other conditions for this purpose of stay.

Highly skilled migrants from outside of the EU

A highly skilled migrant is a migrant who comes to the Netherlands to be employed, and has a gross annual income of at least €47,565, or €34,881 if he/she is under thirty. This income requirement does not apply if the employee enters service for certain functions in an educational or research institution. For information on the specific functions to which this clause applies, you can inquire at the IND office for labour and highly skilled migrants. When a foreign national has been granted residence in the Netherlands as a highly skilled migrant, the employer of the highly skilled migrant is not required to be in possession of a work permit for that foreign national.

Professional soccer players, ministers of religion, teachers of religion and prostitutes are not eligible for a residency as highly skilled migrant.

Important!
The amounts stated above will be indexed every year as of 1 January.