English speaking vacancies in Holland: VACANCY: PhD-student, FHML/School for Cardiovascular Diseases

Wednesday, 2 May 2012

VACANCY: PhD-student, FHML/School for Cardiovascular Diseases

PhD-student, FHML/School for Cardiovascular Diseases (CARIM)/vakgroep Interne Geneeskunde

Specificaties - (uitleg)

Locatie	Maastricht 6200 MD Limburg
Functietypes	PhD positions
Wetenschappelijke discipline	Health
Uren	38.0 uren per week
Salaris	€ 2042 - € 2612
Werk-/denkniveau	University Graduate
Vacaturenummer	AT2012.74
Vertalingen	en

Solliciteer binnen 11 dagen op deze vacature

Functiebeschrijving

The applicant will conduct research in the vascular research group of the dept. of Internal Medicine. This research is embedded in theme Vascular biology of the Cardiovascular Research Institute Maastricht (www.carim.unimaas.nl/).
A growing body of evidence demonstrates that increased adipose mass and the induced expression of adipokines contribute directly towards the burden of insulin resistance and the development of type 2 diabetes. We recently found that the accumulation of the advanced glycation/lipoxidation endproduct (AGEs/ALEs) N-(Carboxymethyl)lysine (CML) in the expanding adipose tissue and activation of the CML-RAGE axis in adipocytes is a novel mechanism contributing to the dysregulation of adipokines. Moreover, activation of the CML-RAGE axis decreased the expression of glyoxalase-1 i.e the enzyme detoxifying the main AGE precursor methylglyoxal (MG), in adipocytes. Our hypothesis is that inhibition of the accumulation of CML and formation of MG leads to amelioration of adipose-tissue derived adipokines and a decreased risk for the development of obesity-associated insulin resistance and type 2 diabetes. The main objectives of this study are to elucidate the association of CML and MG in adipose tissue with progression of insulin resistance and to elucidate whether intervention strategies to inhibit CML and MG accumulation are able to attenuate the development of insulin resistance. We will investigate whether intervention strategies to inhibit CML and MG accumulation are able to attenuate the impaired adipokine-profile in obesity and to improve insulin sensitivity (animal studies) and whether MGO and/or MGO-derived AGEs are directly involved in vascular insulin resistance/signaling (ex-vivo studies). The impact, from a clinical point of view, will be that this study will lead to new possibilities for intervention.

Functie-eisen

Degree in biology, biochemistry, medicine or health sciences. Experience with animal work is a prerequisite and possession of a Laboratory Animal license is an advantage. Subsequent to the PhD project, there will be the possibility for candidates with a degree in medicine of a residency program in Internal Medicine

Arbeidsvoorwaarden

The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website www.maastrichtuniversity.nl/, A-Z Terms of Employment.
Temporary employment for 4 years.
Your salary would be € 2.042,-- gross per month in the first year up to € 2.612,-- gross per month in the fourth year according to the PhD-student salary scale.
Each year an evaluation will take place.

Dienstverband: Temporary, 4 years

Organisatie

http://www.maastrichtuniversity.nl/

Maastricht University is renowned for its unique, innovative, problem-based learning system, which is characterized by a small-scale and student-oriented approach. Research at UM is characterized by a multidisciplinary and thematic approach, and is concentrated in research institutes and schools. Maastricht University has around 14,500 students and 3,800 employees. Reflecting the university's strong international profile, a fair amount of both students and staff are from abroad. The university hosts 6 faculties: Faculty of Health, Medicine and Life Sciences, Faculty of Law, School of Business and Economics, Faculty of Humanities and Sciences, Faculty of Arts and Social Sciences, Faculty of Psychology and Neuroscience.

Additionele informatie

For more information:
Prof Dr. C.G. Schalkwijk, Department of Internal Medicine
email C.Schalkwijk@Maastrichtuniversity.nl
tel: +31 43 3882186

Prof dr CDA Stehouwer, Department of Internal Medicine
email: cda.stehouwer@mumc.nl
tel: +31 43 3877006
For more information about the procedure
Ms M. Berghof
email: martine.berghof@maastrichtuniversity.nl
tel: +31 43 387 2835

Apply here: http://www.academictransfer.com/employer/UM/vacancy/13900/lang/en/

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Introduction of the ‘European Blue Card’

As from 19 June 2011 the Netherlands has a new purpose of stay: the European Blue Card. The European Blue Card is a separate purpose of stay in addition to the existing National Highly Skilled Migrant Programme. The EU Blue Card Council Directive is intended for highly skilled foreign nationals who do not have EU, EEA or Swiss nationality, and who wish to work in one of the member states of the EU. The Directive is also meant to make it easier to settle in another EU member state. A residence permit will always be required in that other member state, however. To obtain this residence permit the employee must comply with the conditions applicable in that member state.

The conditions for residence in the Netherlands as an EU Blue Card holder are stricter than those for residence as a Highly Skilled Migrant. The employee must have a contract for highly qualified employment for at least one year, earning at least EUR 60,000 gross (in 2011). The employee must have completed a course of higher education lasting at least three years. The employee must prove this by having his diploma assessed by Nuffic. For a regulated profession, a competent authority will take decisions about the admission to that profession.

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