PhD-student, FHML/School for Cardiovascular Diseases (CARIM)/vakgroep Interne Geneeskunde
- Specificaties - (uitleg)
Locatie Maastricht 6200 MD Limburg Functietypes PhD positions Wetenschappelijke discipline Health Uren 38.0 uren per week Salaris € 2042 - € 2612 Werk-/denkniveau University Graduate Vacaturenummer AT2012.74 Vertalingen en
Functiebeschrijving
The
applicant will conduct research in the vascular research group of the
dept. of Internal Medicine. This research is embedded in theme Vascular
biology of the Cardiovascular Research Institute Maastricht (www.carim.unimaas.nl/).
A growing body of evidence demonstrates that increased adipose mass and the induced expression of adipokines contribute directly towards the burden of insulin resistance and the development of type 2 diabetes. We recently found that the accumulation of the advanced glycation/lipoxidation endproduct (AGEs/ALEs) N-(Carboxymethyl)lysine (CML) in the expanding adipose tissue and activation of the CML-RAGE axis in adipocytes is a novel mechanism contributing to the dysregulation of adipokines. Moreover, activation of the CML-RAGE axis decreased the expression of glyoxalase-1 i.e the enzyme detoxifying the main AGE precursor methylglyoxal (MG), in adipocytes. Our hypothesis is that inhibition of the accumulation of CML and formation of MG leads to amelioration of adipose-tissue derived adipokines and a decreased risk for the development of obesity-associated insulin resistance and type 2 diabetes. The main objectives of this study are to elucidate the association of CML and MG in adipose tissue with progression of insulin resistance and to elucidate whether intervention strategies to inhibit CML and MG accumulation are able to attenuate the development of insulin resistance. We will investigate whether intervention strategies to inhibit CML and MG accumulation are able to attenuate the impaired adipokine-profile in obesity and to improve insulin sensitivity (animal studies) and whether MGO and/or MGO-derived AGEs are directly involved in vascular insulin resistance/signaling (ex-vivo studies). The impact, from a clinical point of view, will be that this study will lead to new possibilities for intervention.
A growing body of evidence demonstrates that increased adipose mass and the induced expression of adipokines contribute directly towards the burden of insulin resistance and the development of type 2 diabetes. We recently found that the accumulation of the advanced glycation/lipoxidation endproduct (AGEs/ALEs) N-(Carboxymethyl)lysine (CML) in the expanding adipose tissue and activation of the CML-RAGE axis in adipocytes is a novel mechanism contributing to the dysregulation of adipokines. Moreover, activation of the CML-RAGE axis decreased the expression of glyoxalase-1 i.e the enzyme detoxifying the main AGE precursor methylglyoxal (MG), in adipocytes. Our hypothesis is that inhibition of the accumulation of CML and formation of MG leads to amelioration of adipose-tissue derived adipokines and a decreased risk for the development of obesity-associated insulin resistance and type 2 diabetes. The main objectives of this study are to elucidate the association of CML and MG in adipose tissue with progression of insulin resistance and to elucidate whether intervention strategies to inhibit CML and MG accumulation are able to attenuate the development of insulin resistance. We will investigate whether intervention strategies to inhibit CML and MG accumulation are able to attenuate the impaired adipokine-profile in obesity and to improve insulin sensitivity (animal studies) and whether MGO and/or MGO-derived AGEs are directly involved in vascular insulin resistance/signaling (ex-vivo studies). The impact, from a clinical point of view, will be that this study will lead to new possibilities for intervention.
Functie-eisen
Degree
in biology, biochemistry, medicine or health sciences. Experience with
animal work is a prerequisite and possession of a Laboratory Animal
license is an advantage. Subsequent to the PhD project, there will be
the possibility for candidates with a degree in medicine of a residency
program in Internal Medicine
Arbeidsvoorwaarden
The
terms of employment of Maastricht University are set out in the
Collective Labour Agreement of Dutch Universities (CAO). Furthermore,
local UM provisions also apply. For more information look at the website
www.maastrichtuniversity.nl/, A-Z Terms of Employment.
Temporary employment for 4 years.
Your salary would be € 2.042,-- gross per month in the first year up to € 2.612,-- gross per month in the fourth year according to the PhD-student salary scale.
Each year an evaluation will take place.
Dienstverband:
Temporary,
4 years
Temporary employment for 4 years.
Your salary would be € 2.042,-- gross per month in the first year up to € 2.612,-- gross per month in the fourth year according to the PhD-student salary scale.
Each year an evaluation will take place.
Organisatie
http://www.maastrichtuniversity.nl/
Maastricht
University is renowned for its unique, innovative, problem-based
learning system, which is characterized by a small-scale and
student-oriented approach. Research at UM is characterized by a
multidisciplinary and thematic approach, and is concentrated in research
institutes and schools. Maastricht University has around 14,500
students and 3,800 employees. Reflecting the university's strong
international profile, a fair amount of both students and staff are from
abroad. The university hosts 6 faculties: Faculty of Health, Medicine
and Life Sciences, Faculty of Law, School of Business and Economics,
Faculty of Humanities and Sciences, Faculty of Arts and Social Sciences,
Faculty of Psychology and Neuroscience.
Additionele informatie
For more information:
Prof Dr. C.G. Schalkwijk, Department of Internal Medicine
email C.Schalkwijk@Maastrichtuniversity.nl
tel: +31 43 3882186
Prof dr CDA Stehouwer, Department of Internal Medicine
email: cda.stehouwer@mumc.nl
tel: +31 43 3877006
For more information about the procedure
Ms M. Berghof
email: martine.berghof@maastrichtuniversity.nl
tel: +31 43 387 2835
Apply here: http://www.academictransfer.com/employer/UM/vacancy/13900/lang/en/
Prof Dr. C.G. Schalkwijk, Department of Internal Medicine
email C.Schalkwijk@Maastrichtuniversity.nl
tel: +31 43 3882186
Prof dr CDA Stehouwer, Department of Internal Medicine
email: cda.stehouwer@mumc.nl
tel: +31 43 3877006
For more information about the procedure
Ms M. Berghof
email: martine.berghof@maastrichtuniversity.nl
tel: +31 43 387 2835
Apply here: http://www.academictransfer.com/employer/UM/vacancy/13900/lang/en/
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