Job description
Currently
available wound dressing materials, as applied after severe dermal and
sub-dermal injury, are far from ideal. Therefore, adjuvant therapies
need to be explored to improve wound repair. Recently a novel hydrogel,
Heal-x, has been developed (Nature 493, p.651–655). This material is
unique in that its mechanical properties perfectly match those of
collagen and fibrin filaments and is the only gel in the world that
mimics the strain stiffening properties of the natural extracellular
matrix (ECM), controlling cell motility and differentiation. Since these
gels mimic the extracellular microenvironment of humans it can be
expected that they promote tissue integrity and homeostasis. The
specific aim of the PhD track is to perform detailed analyses of the
responses to the micro-environment created by the Heal-X as compared
to currently used dressings. Main study read out parameters include: the
velocity of wound closure, effects on inflammatory, proliferative and
remodelling phase, keratinocyte migration, myofibroblast
formation/apoptosis, and to rule out toxic effects.
available wound dressing materials, as applied after severe dermal and
sub-dermal injury, are far from ideal. Therefore, adjuvant therapies
need to be explored to improve wound repair. Recently a novel hydrogel,
Heal-x, has been developed (Nature 493, p.651–655). This material is
unique in that its mechanical properties perfectly match those of
collagen and fibrin filaments and is the only gel in the world that
mimics the strain stiffening properties of the natural extracellular
matrix (ECM), controlling cell motility and differentiation. Since these
gels mimic the extracellular microenvironment of humans it can be
expected that they promote tissue integrity and homeostasis. The
specific aim of the PhD track is to perform detailed analyses of the
responses to the micro-environment created by the Heal-X as compared
to currently used dressings. Main study read out parameters include: the
velocity of wound closure, effects on inflammatory, proliferative and
remodelling phase, keratinocyte migration, myofibroblast
formation/apoptosis, and to rule out toxic effects.
Requirements
- Master degree in a relevant area: medicine, biomedical sciences, bioengineering, medical biology
- Preferably experience with preclinical models, surgical techniques, wound healing, and/or histology
- An independent and proactive attitude
- Able to work both independently and collaboratively in a multidisciplinary and international team
- Excellent communication skills
- Strong motivation and ambition to succeed in scientific research
- An independent working style, demanding high quality of your own work
- Excellent presentation and scientific writing skills
Conditions of employment
- Salary
is € 2,200 gross per month in the first year up to € 2,818 gross per
month in the fourth year, plus additional vacation bonus (8% per year)
and end of year payments (8,3% per year) - Employment will initially be for one year, and will be extended with an additional 3 years after a positive evaluation
- The employment for this position ideally starts before September 2015
Temporary,
one year
No comments:
Post a Comment